rs10759883 - ERCC6L2-AS1

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide meta-analysis identifies a novel susceptibility signal at CACNA2D3 for nicotine dependence - Unknown journal (n.d.) · Unknown authors · PubMed 28440896

  ABSTRACT: Nicotine dependence (ND) has a reported heritability of 40-70%. Low-coverage whole-genome sequencing was conducted in 1,889 samples from the UCSF Family study. Linear mixed models were used to conduct genome-wide association tests of ND in this and five cohorts obtained from the database of Genotypes and Phenotypes. Fixed-effect meta-analysis was carried out separately for European (n = 14,713) and African (n = 3,369) participants, and then in a combined analysis of both ancestral groups. The meta-analysis of African participants identified a significant and novel susceptibility signal (rs56247223; P = 4.11 × 10−8). Data from the Genotype-Tissue Expression (GTEx) study suggested the protective allele is associated with reduced mRNA expression of CACNA2D3 in three human brain

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