rs10759357 - PALM2AKAP2

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide meta-analysis of monoclonal gammopathy of undetermined significance (MGUS) identifies risk loci impacting IRF-6 - Unknown journal (n.d.) · Unknown authors · PubMed 35418122

  [INTRO] Dear Editor, [INTRO] Monoclonal gammopathy of undetermined significance (MGUS) is a benign plasma cell disorder, common in the Western population (3-5% ≥50 years) and characterized by an asymptomatic clonal plasma cell expansion. MGUS progresses to multiple myeloma (MM) at a rate of 1% per year, but can also progress to light chain amyloidosis (AL amyloidosis), Waldenström macroglobulinemia, and lymphoma. Familial clustering of MGUS or MM support the role for genetic susceptibility. MM and MGUS have shared heritability, with a genetic correlation of 55% and SNP-based heritability estimates of 17% and 15%, respectively (3,4). This suggests a large portion of missing heritability to be identified. Previous genome-wide association studies (GWAS) have successfully identified 24 c

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