Expressive

rs1075855 - ZFHX3

Magnitude 2.2 · 1 study on file

Reported associations

  • Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis - Unknown journal (n.d.) · Unknown authors · PubMed 32541925

    ABSTRACT: We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ethnic meta-analysis of 228,499 cases and 1,178,783 controls in the Million Veteran Program, DIAMANTE, Biobank Japan, and other studies. We report 568 associations, including 286 autosomal, 7 X chromosomal, and 25 identified in ancestry-specific analyses that were previously unreported. Transcriptome-wide association analysis detected 3,568 T2D-associations with genetically predicted gene expression in 687 novel genes; of these, 54 are known to interact with FDA-approved drugs. A polygenic risk score was strongly associated with increased risk of T2D-related retinopathy and modestly associated with chronic kidney disease (CKD), peripheral artery disease (PAD), and neuropathy. We investigated the genetic etiolo

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Exercise

  • Regular aerobic and resistance exercise Moderate

    Physical activity is the primary modifiable prevention factor for type 2 diabetes and improves insulin sensitivity

    150 minutes/week moderate aerobic activity plus 2+ sessions/week resistance training

Lifestyle

  • Maintain healthy weight through balanced diet Moderate

    Weight management directly reduces type 2 diabetes risk and is especially important given genetic predisposition

    Target healthy BMI through calorie-controlled, nutrient-dense whole foods

Screening

  • Regular blood glucose and diabetes screening Moderate

    Genetic risk for type 2 diabetes is managed through early detection enabling timely intervention

    Every 1-3 years depending on age and risk factors, or as recommended by physician