rs10758516 - GLIS3
Magnitude 2.2 · 1 study on file
Reported associations
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Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases - Unknown journal (n.d.) · Unknown authors · PubMed 41644669
ABSTRACT: Thyroid diseases are common and highly heritable. We performed a meta-analysis of genome-wide association studies from 19 biobanks for five thyroid diseases: thyroid cancer (ThC), benign nodular goiter, Graves' disease, lymphocytic thyroiditis and primary hypothyroidism. We analyzed genetic association data from ~2.9 million genomes and identified 313 known and 570 new independent loci linked to thyroid diseases. We discovered genetic correlations between ThC, benign nodular goiter and autoimmune thyroid diseases (rg = 0.16-0.97). Telomere maintenance genes contributed to benign and malignant thyroid nodular disease risk, whereas cell cycle, DNA repair and damage response genes were associated with ThC. We propose a paradigm that explains genetic predisposition to benign
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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Baseline thyroid function testing Moderate
rs10758516 T allele increases hypothyroidism risk through altered GLIS3-AS1 expression in thyroid tissue; early detection enables prompt treatment
Request TSH and free T4 testing from your doctor if not done in past 12 months
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Periodic thyroid function monitoring Moderate
Elevated hypothyroidism risk from T allele requires ongoing surveillance for TSH elevation or symptom emergence
Repeat TSH and free T4 testing every 1-2 years after baseline assessment