rs10757277 - CDKN2B-AS1
Magnitude 2.2 · 1 study on file
Reported associations
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Large-scale genome-wide association study of coronary artery disease in genetically diverse populations - Unknown journal (n.d.) · Unknown authors · PubMed 35915156
ABSTRACT: We report a genome-wide association study (GWAS) of coronary artery disease (CAD) incorporating nearly a quarter million cases, in which existing studies are integrated with data from cohorts of White, Black, and Hispanic individuals from the Million Veteran Program. We document near equivalent heritability of CAD across multiple ancestral groups, identify 95 novel loci, including the first nine to be identified on the X-chromosome, detect the first eight genome-wide significant loci among Blacks and Hispanics, and demonstrate that two common haplotypes at the 9p21 locus are responsible for risk stratification in all populations except those of African origin, where these haplotypes are virtually absent. Moreover, in the largest GWAS for angiographically derived coronary atherosc
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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coronary artery disease genetic risk assessment Moderate
Genome-wide association identified increased CAD predisposition from this CDKN2B-AS1 variant
Discuss genetic findings with healthcare provider; review family history and personal risk factors
Screening
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cardiovascular disease screening Moderate
CDKN2B-AS1 variant associated with increased coronary artery disease risk in large genome-wide association study
Baseline lipid panel, blood pressure measurement, EKG; establish screening frequency with healthcare provider