rs10757260 - MTAP - CDKN2A-AS1

Magnitude 2.2 · 1 study on file

Reported associations

• A genome-wide association study of buccal mucosa cancer in India and multi-ancestry meta-analysis discovers risk loci and gene-environment interactions - Unknown journal (n.d.) · Unknown authors · PubMed 41318233

  ABSTRACT: Summary Background Genome-wide association studies (GWASs) of oral cancers (OC) to date have focused predominantly on European Ancestry (EA) populations. India faces an excess burden of OC, but the most common is the buccal mucosa cancer (BMC), which is relatively rare in EA populations. Methods We conducted a GWAS comprising 2160 BMC cases and 2325 controls from different geographical locations in India. We additionally conducted a GWAS of 397 BMC cases and 439 controls from Taiwan and performed multi-ancestry GWAS meta-analysis of OC on 5255 cases and 8748 controls across EA, Indian and Taiwanese populations. Findings Single SNP analysis of the Indian GWAS discovered a risk locus at 6q27 conferring susceptibility specifically to BMC and identified multiple independent associati

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