rs10756720 - CCDC171
Magnitude 2.2 · 1 study on file
Reported associations
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Beyond apples and pears: sex-specific genetics of body fat percentage - Unknown journal (n.d.) · Unknown authors · PubMed 37867527
ABSTRACT: Introduction Biological sex influences both overall adiposity and fat distribution. Further, testosterone and sex hormone binding globulin (SHBG) influence adiposity and metabolic function, with differential effects of testosterone in men and women. Here, we aimed to perform sex-stratified genome-wide association studies (GWAS) of body fat percentage (BFPAdj) (adjusting for testosterone and sex hormone binding globulin (SHBG)) to increase statistical power. Methods GWAS were performed in white British individuals from the UK Biobank (157,937 males and 154,337 females). To avoid collider bias, loci associated with SHBG or testosterone were excluded. We investigated association of BFPAdj loci with high density cholesterol (HDL), triglyceride (TG), type 2 diabetes (T2D), coronary ar
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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body composition assessment Moderate
rs10756720 risk allele is associated with higher body fat percentage; periodic monitoring enables early awareness of metabolic changes
baseline assessment and repeat annually via DEXA, bioimpedance, or comparable objective method