Expressive

rs10756193 - DMRT2 - RPS27AP14

Magnitude 2.2 · 1 study on file

Reported associations

  • Ancestry- and sex-specific effects underlying inguinal hernia susceptibility identified in a multiethnic genome-wide association study meta-analysis - Unknown journal (n.d.) · Unknown authors · PubMed 35022708

    ABSTRACT: Abstract Inguinal hernias are some of the most frequently diagnosed conditions in clinical practice and inguinal hernia repair is the most common procedure performed by general surgeons. Studies of inguinal hernias in non-European populations are lacking, though it is expected that such studies could identify novel loci. Further, the cumulative lifetime incidence of inguinal hernia is nine times greater in men than women, however, it is not clear why this difference exists. We conducted a genome-wide association meta-analysis of inguinal hernia risk across 513 120 individuals (35 774 cases and 477 346 controls) of Hispanic/Latino, African, Asian and European descent, with replication in 728 418 participants (33 491 cases and 694 927 controls) from the 23andMe, Inc dat

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • inguinal hernia risk with your doctor Moderate

    This SNP increases genetic susceptibility to inguinal hernia; clinical discussion helps establish personalized monitoring and prevention strategies.

    • GWAS_CATALOG:35022708

Lifestyle

  • heavy lifting and intense straining activities Moderate

    Heavy lifting and straining increase intra-abdominal pressure acutely; these are known triggers for hernia formation in susceptible individuals.

    Use proper technique; avoid lifting over 50 pounds regularly; manage constipation to prevent straining

    • GWAS_CATALOG:35022708
  • maintain healthy body weight Moderate

    Obesity increases intra-abdominal pressure, a known risk factor for inguinal hernia; maintaining healthy weight reduces hernia risk independent of genetic factors.

    Target BMI of 18.5-24.9 kg/m2

    • GWAS_CATALOG:35022708

Screening

  • monitor for inguinal hernia symptoms Moderate

    Genetic predisposition increases likelihood of hernia development; early symptom detection enables timely medical evaluation and intervention.

    Be alert for groin bulge, pain or heaviness, especially with physical exertion; report to doctor if noticed

    • GWAS_CATALOG:35022708