rs1075550 - FGF23 - FGF6
Magnitude 2.2 · 1 study on file
Reported associations
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New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis - Unknown journal (n.d.) · Unknown authors · PubMed 34294844
ABSTRACT: Migraine is a common disabling primary headache disorder that is ranked as the most common neurological cause of disability worldwide. Women present with migraine much more frequently than men, but the reasons for this difference are unknown. Migraine heritability is estimated to up to 57%, yet much of the genetic risk remains unaccounted for, especially in non-European ancestry populations. To elucidate the etiology of this common disorder, we conduct a multiethnic genome-wide association meta-analysis of migraine, combining results from the GERA and UK Biobank cohorts, followed by a European-ancestry meta-analysis using public summary statistics. We report 79 loci associated with migraine, of which 45 were novel. Sex-stratified analyses identify three additional novel loci (CPS
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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migraine risk and personalized prevention strategy Moderate
Genetic risk information can guide selection of appropriate preventive approaches for this individual.
Discuss with healthcare provider; consider preventive medications or lifestyle interventions based on individual factors.
Screening
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migraine symptoms and frequency Moderate
This SNP is strongly associated with increased migraine susceptibility in GWAS of nearly 900,000 individuals.
If headaches develop, maintain symptom diary tracking frequency, duration, triggers, and characteristics.