rs10753805 - LINC01681 - HAUS4P1
Magnitude 2.2 · 1 study on file
Reported associations
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Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry - Unknown journal (n.d.) · Unknown authors · PubMed 30239722
ABSTRACT: Abstract More than one in three adults worldwide is either overweight or obese. Epidemiological studies indicate that the location and distribution of excess fat, rather than general adiposity, are more informative for predicting risk of obesity sequelae, including cardiometabolic disease and cancer. We performed a genome-wide association study meta-analysis of body fat distribution, measured by waist-to-hip ratio (WHR) adjusted for body mass index (WHRadjBMI), and identified 463 signals in 346 loci. Heritability and variant effects were generally stronger in women than men, and we found approximately one-third of all signals to be sexually dimorphic. The 5% of individuals carrying the most WHRadjBMI-increasing alleles were 1.62 times more likely than the bottom 5% to have a WHR
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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waist-to-hip ratio Moderate
Variant associated with increased waist-to-hip ratio adjusted for BMI, a marker of central adiposity and metabolic risk
Obtain waist-to-hip measurement annually; calculate as waist circumference divided by hip circumference