rs10750441 - BAK1P2 - LINC02873
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk - Unknown journal (n.d.) · Unknown authors · PubMed 28135244
ABSTRACT: Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. Combined with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine appr
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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pulse pressure and arterial stiffness Moderate
The T allele at rs10750441 is associated with significantly elevated pulse pressure, a marker of arterial stiffness and cardiovascular disease risk
Annual blood pressure assessment; calculate and track pulse pressure; discuss arterial stiffness evaluation with clinician