Expressive

rs10749553 - MINPP1 - RPS26P38

Magnitude 4.5 · 2 studies on file

Reported associations

  • Potential genetic biomarkers are found to be associated with both cognitive function and blood pressure: A bivariate genome-wide association analysis. - Mechanisms of ageing and development (2022) · Zhang L, Wang W, Xu C, Duan H, Tian X, Zhang D · PubMed 35364053

    A bivariate genome-wide association study was conducted in 137 pairs of twins to explore the shared genetic loci between cognition and blood pressure (BP). Before SNPs imputation, rs72815554 is significantly (P < 5 × 10 ) associated with the cognition-pulse pressure (PP) phenotype, while after imputation, 4 and 9 SNPs are significantly associated with the cognition-SBP phenotype, and cognition-PP phenotype, respectively, including rs72815554. There existed SNPs with highly linkage disequilibrium (LD) of rs10998339, rs72815554, rs11665292, and rs10823231. Besides, rs10998347, rs12153038, and rs10998295 had higher RegulomeDB scores and are located in the transcription factors binding regions. Rs7574283 and rs58113664 are located in the super-enhancer regions which are expressed highly i

  • Generalized correlation coefficient for genome-wide association analysis of cognitive ability in twins - Unknown journal (n.d.) · Unknown authors · PubMed 33232274

    ABSTRACT: Despite a strong genetic background in cognitive function only a limited number of single nucleotide polymorphisms (SNPs) have been found in genome-wide association studies (GWASs). We hypothesize that this is partially due to mis-specified modeling concerning phenotype distribution as well as the relationship between SNP dosage and the level of the phenotype. To overcome these issues, we introduced an assumption-free method based on generalized correlation coefficient (GCC) in a GWAS of cognitive function in Danish and Chinese twins to compare its performance with traditional linear models. The GCC-based GWAS identified two significant SNPs in Danish samples (rs71419535, p = 1.47e-08; rs905838, p = 1.69e-08) and two significant SNPs in Chinese samples (rs2292999, p = 9.27e-10; r

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.