Expressive

rs10747625 - NR4A1 - ATG101

Magnitude 2.8 · 1 study on file

Reported associations

  • Genetic association study identifies genetic variants for non-alcoholic fatty liver without comorbidities in the Korean population. - Genes & genomics (2023) · Kim YJ, Cho YS · PubMed 37133724

    Non-alcoholic fatty liver (NAFL) refers to a disease in which fat builds up in the liver, similar to what occurs for those who drink a lot of alcohol, even in cases of not drinking alcohol at all or only in a small amount. Along with non-alcoholic steatohepatitis (NASH), NAFL is a type of non-alcoholic fatty liver disease (NAFLD). Currently, the prevalence of NAFLD is increasing worldwide. A wide range of comorbidities that can increase the risk of NAFLD includes obesity, type 2 diabetes, dyslipidemia, and metabolic syndrome. This study aimed to discover genetic variants for NAFL in the Korean population. Differing from previous studies, we conducted a genome-wide association study for NAFL in the selected subjects without comorbidities to rule out bias due to the inclusion of confounding

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Exercise

  • Regular aerobic and resistance exercise for hepatic health Moderate

    Exercise reduces hepatic steatosis independent of weight loss; essential for NAFLD genetic risk

    150 minutes/week moderate-intensity aerobic activity; 2x/week resistance training

Lifestyle

  • Maintain healthy body weight through dietary management Moderate

    Weight loss is first-line NAFLD therapy; genetic risk warrants proactive weight management

    Target BMI 18.5-24.9 kg/m2; pursue 5-10% weight reduction if overweight

Screening

  • NAFLD risk assessment and liver imaging Moderate

    Genetic risk allele A associated with 38% increased odds of nonalcoholic fatty liver disease

    Baseline abdominal ultrasound or transient elastography; repeat if abnormal findings