rs10747572 - LIMA1

Magnitude 2.2 · 1 study on file

Reported associations

• Insights from a Large-Scale Whole Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension - Unknown journal (n.d.) · Unknown authors · PubMed 35652341

  ABSTRACT: Background: The availability of whole genome sequencing data in large studies has enabled the assessment of coding and non-coding variants across the allele frequency spectrum for their associations with blood pressure. Methods: We conducted a multi-ancestry whole genome sequencing analysis of blood pressure among 51,456 Trans-Omics for Precision Medicine and Centers for Common Disease Genomics program participants (stage-1). Stage-2 analyses leveraged array data from UK Biobank (N=383,145), Million Veteran Program (N= 318,891), and Reasons for Geographic and Racial Differences in Stroke (N=10,643) participants, along with whole exome sequencing data from UK Biobank (N=199,631) participants. Results: Two blood pressure signals achieved genome-wide significance in meta-analyses of

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