Expressive

rs10747570 - COX14

Magnitude 2.2 · 2 studies on file

Reported associations

  • Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation - Unknown journal (n.d.) · Unknown authors · PubMed 27841878

    ABSTRACT: Longitudinal electronic health records on 99,785 Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort individuals provided 1,342,814 systolic and diastolic blood pressure measurements for a genome-wide association study on long-term average systolic, diastolic, and pulse pressure. We identified 39 novel among 75 significant loci (P≤5×10−8), most replicating in the combined International Consortium for Blood Pressure (ICBP, n=69,396) and UK Biobank (UKB, n=152,081) studies. Combining GERA with ICBP yielded 36 additional novel loci, most replicating in UKB. Combining all three studies (n=321,262) yielded 241 additional genome-wide significant loci, although for these no replication sample was available. All associated loci explained 2.9%/2.5%/3.1% of systolic/

  • Trans-ethnic association study of blood pressure determinants in over 750,000 individuals - Unknown journal (n.d.) · Unknown authors · PubMed 30578418

    ABSTRACT: In this trans-ethnic multi-omic study we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenome, and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in GWASs of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically-predicted gene expression of 840 genes in 45 tissues, and murine renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells. Editorial summary: Analysis of blood pressure data from

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • DASH diet or sodium-restricted eating pattern Moderate

    Dietary approaches reduce blood pressure; particularly relevant for individuals with genetic predisposition to elevated BP

    Emphasize vegetables, whole grains, lean proteins; limit sodium to <2300 mg daily or follow DASH pattern

Discuss with your doctor

  • cardiovascular risk assessment and hypertension prevention Moderate

    Genetic association with elevated blood pressure warrants personalized evaluation for additional cardiovascular risk factors and prevention strategies

    Discuss with healthcare provider to review family history, current BP readings, and appropriate management plan

Exercise

  • regular aerobic exercise for blood pressure management Moderate

    Aerobic exercise reduces blood pressure and cardiovascular disease risk across all populations; beneficial for genetic BP elevation

    Aim for 150 minutes of moderate-intensity aerobic activity per week (brisk walking, cycling, swimming, jogging)

Screening

  • systolic blood pressure monitoring Moderate

    rs10747570 A allele associates with elevated systolic blood pressure (0.293 mmHg per allele, p=3e-17, n=459,777)

    Check blood pressure at least annually; more frequently if elevated or family history of hypertension