rs10746102 - ASCL4 - WSCD2
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide analyses of multiple obesity-related cytokines and hormones informs biology of cardiometabolic traits - Unknown journal (n.d.) · Unknown authors · PubMed 34620218
ABSTRACT: Background A complex set of perturbations occur in cytokines and hormones in the etiopathogenesis of obesity and related cardiometabolic conditions such as type 2 diabetes (T2D). Evidence for the genetic regulation of these cytokines and hormones is limited, particularly in African-ancestry populations. In order to improve our understanding of the biology of cardiometabolic traits, we investigated the genetic architecture of a large panel of obesity- related cytokines and hormones among Africans with replication analyses in African Americans. Methods We performed genome-wide association studies (GWAS) in 4432 continental Africans, enrolled from Ghana, Kenya, and Nigeria as part of the Africa America Diabetes Mellitus (AADM) study, for 13 obesity-related cytokines and hormones, in
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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Fasting insulin and glucose screening Moderate
Rs10746102 risk allele C associates with elevated fasting insulin levels in overweight individuals, indicating altered glucose homeostasis and metabolic risk
Obtain baseline fasting insulin and glucose; repeat annually or per clinical guideline