rs10744434 - VPS37B
Magnitude 2.2 · 1 study on file
Reported associations
-
Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation - Unknown journal (n.d.) · Unknown authors · PubMed 40645996
ABSTRACT: Atrial fibrillation (AF) is a common cardiac arrhythmia with strong genetic components, yet its underlying molecular mechanisms and potential therapeutic targets remain incompletely understood. We conducted a cross-population genome-wide meta-analysis of 252,438 AF cases and identified 525 loci that met genome-wide significance. Two loci of PITX2 and ZFHX3 genes were identified as shared across populations of different ancestries. Comprehensive gene prioritization approaches reinforced the role of muscle development and heart contraction while also uncovering additional pathways, including cellular response to transforming growth factor-beta. Population-specific genetic correlations uncovered common and unique circulatory comorbidities between Europeans and Africans. Mendelian ra
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
-
AF risk assessment and monitoring strategy Moderate
Genetic variant rs10744434 is associated with increased atrial fibrillation risk
Consult with cardiologist to assess individual AF risk factors and establish personalized monitoring plan
Screening
-
ECG screening for atrial fibrillation Moderate
VPS37B variant associated with increased AF risk in large genome-wide association study of 1.84 million subjects
Baseline ECG and annual re-screening or per cardiologist recommendation