rs10744391 - SLC15A4 - GLT1D1

Magnitude 2.2 · 1 study on file

Reported associations

• Heritability and genome-wide association analysis of renal sinus fat accumulation in the Framingham Heart Study - Unknown journal (n.d.) · Unknown authors · PubMed 22044751

  ABSTRACT: Background Ectopic fat accumulation in the renal sinus is associated with chronic kidney disease and hypertension. The genetic contributions to renal sinus fat accumulation in humans have not been well characterized. Methods The present analysis consists of participants from the Framingham Offspring and Third Generation who underwent computed tomography; renal sinus fat and visceral adipose tissue (VAT) were quantified. Renal sinus fat was natural log transformed and sex- and cohort-specific residuals were created, adjusted for (1) age, (2) age and body mass index (BMI), and (3) age and VAT. Residuals were pooled and used to calculate heritability using variance-components analysis in SOLAR. A genome-wide association study (GWAS) for renal sinus fat was performed using an additiv

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