rs10744213 - TMEM132B
Magnitude 2.2 · 1 study on file
Reported associations
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Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration - Unknown journal (n.d.) · Unknown authors · PubMed 31719535
ABSTRACT: Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint analyses, we identify 49 previously unreported lipid loci, and 10 additional previously unreported lipid loci in a restricted sample of European-ancestry cohorts. In addition, we identify new gene-sleep interactions for known lipid loci such as LPL and PCSK9. The previously unreported lip
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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triglyceride levels Moderate
Genetic variant rs10744213 in TMEM132B associates with triglyceride metabolism, especially under short sleep duration
Check fasting triglycerides annually or as recommended by healthcare provider
Lifestyle
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adequate sleep duration Moderate
TMEM132B rs10744213 interacts with sleep duration to modulate triglyceride levels; inadequate sleep amplifies metabolic risk
Aim for 7-9 hours nightly; maintain consistent sleep schedule