rs10741243 - TCERG1L
Magnitude 4.5 · 1 study on file
Reported associations
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Transferability of Type 2 Diabetes Implicated Loci in Multi-Ethnic Cohorts from Southeast Asia - Unknown journal (n.d.) · Unknown authors · PubMed 21490949
ABSTRACT: Recent large genome-wide association studies (GWAS) have identified multiple loci which harbor genetic variants associated with type 2 diabetes mellitus (T2D), many of which encode proteins not previously suspected to be involved in the pathogenesis of T2D. Most GWAS for T2D have focused on populations of European descent, and GWAS conducted in other populations with different ancestry offer a unique opportunity to study the genetic architecture of T2D. We performed genome-wide association scans for T2D in 3,955 Chinese (2,010 cases, 1,945 controls), 2,034 Malays (794 cases, 1,240 controls), and 2,146 Asian Indians (977 cases, 1,169 controls). In addition to the search for novel variants implicated in T2D, these multi-ethnic cohorts serve to assess the transferability and relevan
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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Limit refined carbohydrates and added sugars Moderate
High glycemic load increases postprandial glucose and insulin demand in diabetes-susceptible individuals
Reduce sugary beverages and refined grains; choose whole grain carbohydrates
Exercise
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Regular aerobic and resistance exercise Moderate
Physical activity improves insulin sensitivity and glucose metabolism in individuals with genetic T2D risk
150 minutes moderate-intensity aerobic exercise plus 2-3 days resistance training weekly
Screening
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Diabetes screening (fasting glucose or HbA1c) Moderate
Genetic variant significantly associated with type 2 diabetes risk (1.75-fold increased odds)
Test annually starting at age 30