Expressive

rs10738454 - BNC2

Magnitude 2.2 · 1 study on file

Reported associations

  • Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank. - Hernia : the journal of hernias and abdominal wall surgery (2022) · Wei J, Attaar M, Shi Z, Na R, Resurreccion WK, Haggerty SP, Zheng SL, Helfand BT, Ujiki MB, Xu J · PubMed 34382107

    Familial aggregation is known for both hernia development and recurrence. To date, only one genome-wide association study (GWAS) limited to inguinal hernia has been reported that identified four risk-associated loci. We aim to investigate polygenic architecture of abdominal wall hernia development and recurrence. A GWAS was performed in 367,394 subjects from the UK Biobank to investigate the polygenic architecture of abdominal wall hernia subtypes (inguinal, femoral, umbilical, ventral) and identify specific single nucleotide polymorphisms (SNPs) that are associated with their risk. Expression quantitative trait loci (eQTL) analysis was performed to identify genes whose expression levels are associated with these SNPs. A genetic risk score (GRS) was used to assess the cumulative effect of

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • inguinal hernia risk assessment and prevention Moderate

    genetic predisposition confirmed by large GWAS; clinical assessment enables personalized screening and early detection

    • GWAS_CATALOG:34382107

Exercise

  • strenuous heavy lifting Moderate

    rs10738454 risk allele increases inguinal hernia susceptibility; mechanical strain activates hernia development in predisposed individuals

    avoid heavy lifting and strenuous core exercises; consult physical therapist for safe modifications

    • GWAS_CATALOG:34382107

Lifestyle

  • maintain healthy weight Moderate

    excess abdominal weight elevates intra-abdominal pressure, increasing hernia risk in genetically susceptible individuals

    maintain BMI 18.5-24.9 through balanced diet and regular aerobic exercise

    • GWAS_CATALOG:34382107