rs10738186 - PTPRD-DT - IMP3P1

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide association study identifies a regulatory variant of RGMA associated with opioid dependence in European Americans - Unknown journal (n.d.) · Unknown authors · PubMed 29478698

  ABSTRACT: Background Opioid dependence (OD) is at epidemic levels in the United States. Genetic studies can provide insight into its biology. Methods We completed an OD genome-wide association study (GWAS) in 3058 opioid-exposed European-Americans, 1290 of whom met criteria for a DSM-IV diagnosis of OD. Analysis used DSM-IV criterion count. Results By meta-analysis of four cohorts, Yale-Penn 1 (n=1388), Yale-Penn 2 (n=996), Yale-Penn 3 (n=98) and SAGE (n=576), we identified a variant on chromosome 15, rs12442183, near RGMA (repulsive guidance molecule A (RGMa)), associated with OD (P=1.3×10-8). The association was also genome-wide significant (GWS) in Yale-Penn 1 taken individually, and nominally significant in two of the other three samples. The finding was further supported in a meta-an

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