rs10736303 - FGFR2

Magnitude 2.2 · 1 study on file

Reported associations

• Considering hormone-sensitive cancers as a single disease in the UK biobank reveals shared aetiology - Unknown journal (n.d.) · Unknown authors · PubMed 35729236

  ABSTRACT: Hormone-related cancers, including cancers of the breast, prostate, ovaries, uterine, and thyroid, globally contribute to the majority of cancer incidence. We hypothesize that hormone-sensitive cancers share common genetic risk factors that have rarely been investigated by previous genomic studies of site-specific cancers. Here, we show that considering hormone-sensitive cancers as a single disease in the UK Biobank reveals shared genetic aetiology. We observe that a significant proportion of variance in disease liability is explained by the genome-wide single nucleotide polymorphisms (SNPs), i.e., SNP-based heritability on the liability scale is estimated as 10.06% (SE 0.70%). Moreover, we find 55 genome-wide significant SNPs for the disease, using a genome-wide association stud

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