Expressive

rs10734649 - LINC02709, SBF2-AS1

Magnitude 2.2 · 1 study on file

Reported associations

  • Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease - Unknown journal (n.d.) · Unknown authors · PubMed 29212778

    ABSTRACT: Supplemental Digital Content is available in the text. Rationale: Coronary artery disease (CAD) is a complex phenotype driven by genetic and environmental factors. Ninety-seven genetic risk loci have been identified to date, but the identification of additional susceptibility loci might be important to enhance our understanding of the genetic architecture of CAD. Objective: To expand the number of genome-wide significant loci, catalog functional insights, and enhance our understanding of the genetic architecture of CAD. Methods and Results: We performed a genome-wide association study in 34 541 CAD cases and 261 984 controls of UK Biobank resource followed by replication in 88 192 cases and 162 544 controls from CARDIoGRAMplusC4D. We identified 75 loci that replicated and

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • Lipid panel and fasting glucose Moderate

    Lipid and glucose metabolism are key modifiable CAD risk factors for carriers of this genetic variant

    Annual monitoring, or biennial if stable and within healthy ranges

Discuss with your doctor

  • Genetic contribution to coronary artery disease risk Moderate

    This variant is independently associated with increased CAD risk in large population-based studies

Exercise

  • Regular aerobic exercise Moderate

    Aerobic exercise reduces CAD risk and improves cardiovascular fitness in genetically at-risk individuals

    150 minutes moderate-intensity or 75 minutes vigorous-intensity aerobic activity weekly

Lifestyle

  • Heart-healthy dietary pattern Moderate

    Variant associated with CAD risk; dietary modifications reduce cardiovascular disease incidence in at-risk populations

    Mediterranean or DASH pattern diet emphasizing plant foods, fish, and limiting saturated fats and sodium

Screening

  • Cardiovascular risk assessment Moderate

    Variant associated with increased coronary artery disease susceptibility via altered cardiovascular gene expression

    Discuss with healthcare provider about timing of cardiovascular screening and risk stratification