rs10734030 - PLXDC2-AS1, PLXDC2

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association study reveals two novel genetic loci associated with chronic lung allograft dysfunction. - The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation (2026) · Brocard S, Mauduit V, Morin M, Boussamet L, Silva NDSB, Durand A, Halitim P, Renaud-Picard B, Coiffard B, Demant X, Falque L, Le Pavec J, Roux A, Villeneuve T, Knoop C, Merveilleux C, Salpin M, Carlier N, Gourraud PA, Magnan A, Lair D, Berthelot L, Südholt M, Vince N, Tissot A, Limou S · PubMed 41864285

  Chronic lung allograft dysfunction (CLAD) leads to declining respiratory function and high mortality, representing the main barrier to long-term survival in lung transplantation (LT). We performed the first genome-wide association study (GWAS) investigating donor's and recipient's genetic factors associated with CLAD. We genotyped 392 donor-recipient pairs from the multicentric Cohort in Lung Transplantation. We tested 4.5 million SNPs for association with CLAD using multivariable logistic regression models corrected for age, sex, initial disease and genetic ancestry. Three levels of explanatory variables were separately considered to conduct GWAS: donors-only, recipients-only, and donor-recipient mismatches. We also ran HLA-centric analyses using the same models. Our analysis confirmed th

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