rs10733604 - PRPF4

Magnitude 2.0 · 1 study on file

Reported associations

• Genetic associations with childhood brain growth, defined in two longitudinal cohorts - Genetic epidemiology (2018) · Szekely E, Schwantes-An TL, Justice CM, Sabourin JA, Jansen PR, Muetzel RL, Sharp W, Tiemeier H, Sung H, White TJ, Wilson AF, Shaw P · PubMed 29682794

  ABSTRACT: Genome-wide association studies (GWAS) are unraveling the genetics of adult brain neuroanatomy as measured by cross-sectional anatomic magnetic resonance imaging (aMRI). However, the genetic mechanisms that shape childhood brain development are, as yet, largely unexplored. In this study we identify common genetic variants associated with childhood brain development as defined by longitudinal aMRI. Genome-wide SNP data were determined in 2 cohorts: one enriched for attention-deficit/hyperactivity disorder (ADHD) (LONG cohort: 458 participants; 119 with ADHD) and the other from a population-based cohort (Generation R: 257 participants). The growth of the brain's major regions (cerebral cortex, white matter, basal ganglia and cerebellum) and one region of interest (the right later

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