Expressive

rs10692578 - EBF2

Magnitude 2.2 · 1 study on file

Reported associations

  • Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank. - Hernia : the journal of hernias and abdominal wall surgery (2022) · Wei J, Attaar M, Shi Z, Na R, Resurreccion WK, Haggerty SP, Zheng SL, Helfand BT, Ujiki MB, Xu J · PubMed 34382107

    Familial aggregation is known for both hernia development and recurrence. To date, only one genome-wide association study (GWAS) limited to inguinal hernia has been reported that identified four risk-associated loci. We aim to investigate polygenic architecture of abdominal wall hernia development and recurrence. A GWAS was performed in 367,394 subjects from the UK Biobank to investigate the polygenic architecture of abdominal wall hernia subtypes (inguinal, femoral, umbilical, ventral) and identify specific single nucleotide polymorphisms (SNPs) that are associated with their risk. Expression quantitative trait loci (eQTL) analysis was performed to identify genes whose expression levels are associated with these SNPs. A genetic risk score (GRS) was used to assess the cumulative effect of

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Weight management to reduce hernia risk Moderate

    Excess body weight increases intra-abdominal pressure; combined with genetic predisposition, weight management reduces inguinal hernia development risk

    Target healthy BMI through balanced diet and regular exercise; consult physician for personalized goals

Lifestyle

  • Heavy lifting and straining activities Moderate

    Genetic variant rs10692578 increases inguinal hernia risk; mechanical pressure from heavy lifting exacerbates hernia development in predisposed individuals

    Limit repetitive heavy lifting; use proper form for essential lifting; minimize straining activities

Screening

  • Inguinal hernia screening Moderate

    Genetic variant rs10692578 increases inguinal hernia odds by 16 percent; early detection through clinical screening enables preventive management

    Include inguinal examination during routine medical visits; report any bulge or discomfort in groin area