rs10670352 - PLA2G12B - P4HA1
Magnitude 2.8 · 1 study on file
Reported associations
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Dyslipidaemia-Genotype Interactions with Nutrient Intake and Cerebro-Cardiovascular Disease - Unknown journal (n.d.) · Unknown authors · PubMed 35884923
ABSTRACT: A comprehensive understanding of gene-diet interactions is necessary to establish proper dietary guidelines to prevent and manage cardio-cerebrovascular disease (CCD). We investigated the role of genetic variants associated with dyslipidaemia (DL) and their interactions with macro-nutrients for cardiovascular disease using a large-scale genome-wide association study of Korean adults. A total of 58,701 participants from a Korean genome and epidemiology study were included. Their dietary intake was assessed using a food frequency questionnaire. Dyslipidaemia was defined as total cholesterol (TCHL) ≥ 240 mg/dL, high-density lipoprotein (HDL) < 40 mg/dL, low-density lipoprotein (LDL) ≥ 160 mg/dL, triglycerides (TG) ≥ 200 mg/dL, or dyslipidaemia history. Their nutrient intake wa
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Cholesterol management strategy Moderate
Genetic predisposition to higher total cholesterol requires individualized risk assessment and management approach.
Screening
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Total cholesterol levels Moderate
Genetic variant associated with elevated total cholesterol in 58,701-person cohort; baseline and periodic monitoring enables early intervention.
Obtain lipid panel; retest per healthcare provider guidance