rs1065489 - CFH

Magnitude 2.2 · 1 study on file

Reported associations

• Exome array identifies functional exonic biomarkers for pediatric dental caries. - Computers in biology and medicine (2022) · Borgio JF, Alsuwat HS, Alamoudi W, Hegazi FM, Al Otaibi WM, M Ibrahim A, Almandil NB, Al-Amodi AM, Alyousef YM, AlShwaimi E, Almasoud N, Kamaraj B, Sayed A · PubMed 34749984

  Pediatric dental caries is common among Arab children, however we are still searching for possible genes and molecular mechanisms that influence caries development. To identity genetic predispositions of dental caries among Saudi children with high DMFT (Decayed, Missing, and Filled Teeth). This case-control study analysed putative functional exonic-variants (n = 243,345) to study the molecular genetics of pediatric caries with high dmft index, 8.75 ± 4.16 on Arab-ancestry subjects with primary dentition (n = 111; 76 cases, dmft>5 and 35 controls, dmft = 0). Pediatric caries is significantly associated with single nucleotide polymorphisms (SNP) in the GRIN2B-rs4764039C (p-value = 2.03 × 10 ) and CFH-rs1065489G (p-value = 8.26 × 10 ) genes, even after Bonferroni correctio

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