Expressive

rs1065314 - SYN3, TIMP3

Magnitude 4.5 · 1 study on file

Reported associations

  • Identification of female-specific genetic variants for metabolic syndrome and its component traits to improve the prediction of metabolic syndrome in females - Unknown journal (n.d.) · Unknown authors · PubMed 31170924

    ABSTRACT: Background Metabolic syndrome (MetS), defined as a cluster of metabolic risk factors including dyslipidemia, insulin-resistance, and elevated blood pressure, has been known as partly heritable. MetS effects the lives of many people worldwide, yet females have been reported to be more vulnerable to this cluster of risks. Methods To elucidate genetic variants underlying MetS specifically in females, we performed a genome-wide association study (GWAS) for MetS as well as its component traits in a total of 9932 Korean female subjects (including 2276 MetS cases and 1692 controls). To facilitate the prediction of MetS in females, we calculated a genetic risk score (GRS) combining 14 SNPs detected in our GWA analyses specific for MetS. Results GWA analyses identified 14 moderate signals

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Reduce refined carbohydrates and added sugars Moderate

    Dietary reduction in refined carbohydrates is effective for lowering triglycerides, which are elevated in carriers of rs1065314-C

    Prioritize whole grains, legumes, and fiber; limit sugary beverages and refined grains

Discuss with your doctor

  • Triglyceride management strategy Moderate

    This SNP is associated with elevated triglyceride levels in females; personalized management addressing lifestyle and potentially pharmacotherapy may be indicated

Exercise

  • Regular aerobic exercise Moderate

    Aerobic exercise lowers triglyceride levels, which are elevated in rs1065314-C carriers

    150+ minutes moderate-intensity aerobic activity weekly

Screening

  • Triglyceride levels Moderate

    rs1065314-C is strongly associated with elevated triglyceride levels in females (14.58 mg/dL increase per C allele, p=2.41e-07)

    Annual screening; consider more frequent monitoring if baseline elevated