rs10648051 - HMGB1P47 - RNA5SP182

Magnitude 2.2 · 1 study on file

Reported associations

• Trans-ancestry GWAS identifies 59 loci and improves risk prediction and fine-mapping for kidney stone disease - Unknown journal (n.d.) · Unknown authors · PubMed 40216741

  ABSTRACT: Kidney stone disease is a multifactorial disease with increasing incidence worldwide. Trans-ancestry GWAS has become a popular strategy to dissect genetic structure of complex traits. Here, we conduct a large trans-ancestry GWAS meta-analysis on kidney stone disease with 31,715 cases and 943,655 controls in European and East Asian populations. We identify 59 kidney stone disease susceptibility loci, including 13 novel loci and show similar effects across populations. Using fine-mapping, we detect 1612 variants at these loci, and pinpoint 25 causal signals with a posterior inclusion probability >0.5 among them. At a novel locus, we pinpoint TRIOBP gene and discuss its potential link to kidney stone disease. We show that a cross-population polygenic risk score, PRS-CSxEAS&EUR, exhi

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