rs1064346 - OSTM1; OSTM1; OSTM1; OSTM1; OSTM1; OSTM1-AS1; OSTM1; OSTM1; OSTM1; OSTM1; OSTM1-AS1; OSTM1; OSTM1-AS1; OSTM1; OSTM1-AS1; OSTM1; OSTM1; OSTM1; RPL3P7 - OSTM1; OSTM1; OSTM1; OSTM1; OSTM1; OSTM1; RPL3P7 - OSTM1; OSTM1; OSTM1; RPL3P7 - OSTM1; OSTM1; OSTM1; OSTM1-AS1; OSTM1
Magnitude 2.8 · 1 study on file
Reported associations
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Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 29187746
ABSTRACT: Genome-wide association studies using genotype data have had limited success in the identification of variants associated with major depressive disorder (MDD). Haplotype data provide an alternative method for detecting associations between variants in weak linkage disequilibrium with genotyped variants and a given trait of interest. A genome-wide haplotype association study for MDD was undertaken utilising a family-based population cohort, Generation Scotland: Scottish Family Health Study (n = 18,773), as a discovery cohort with UK Biobank used as a population-based replication cohort (n = 25,035). Fine mapping of haplotype boundaries was used to account for overlapping haplotypes potentially tagging the same causal variant. Within the discovery cohort, two haplotypes exc
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Genetic risk for major depressive disorder Moderate
rs1064346 A allele demonstrates GWAS-level association with increased MDD risk
Discuss genetic findings with primary care provider to establish appropriate monitoring and prevention strategy
Screening
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Depression screening Moderate
rs1064346 A allele associated with 26% increased major depressive disorder risk (n=18773, p=3e-7)
Annual depression screening; baseline PHQ-9 or similar validated assessment