Expressive

rs10641969 - MAML3

Magnitude 2.2 · 2 studies on file

Reported associations

  • GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression - Unknown journal (n.d.) · Unknown authors · PubMed 33608531

    ABSTRACT: Genetic factors are recognized to contribute to peptic ulcer disease (PUD) and other gastrointestinal diseases, such as gastro-oesophageal reflux disease (GORD), irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Here, genome-wide association study (GWAS) analyses based on 456,327 UK Biobank (UKB) individuals identify 8 independent and significant loci for PUD at, or near, genes MUC1, MUC6, FUT2, PSCA, ABO, CDX2, GAST and CCKBR. There are previously established roles in susceptibility to Helicobacter pylori infection, response to counteract infection-related damage, gastric acid secretion or gastrointestinal motility for these genes. Only two associations have been previously reported for duodenal ulcer, here replicated trans-ancestrally. The results highlight t

  • Genetic diversity fuels gene discovery for tobacco and alcohol use - Unknown journal (n.d.) · Unknown authors · PubMed 36477530

    ABSTRACT: Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury. These substances are used across the globe, yet genome-wide association studies have focused largely on individuals of European ancestries. Here we leveraged global genetic diversity across 3.4 million individuals from four major clines of global ancestry (approximately 21% non-European) to power the discovery and fine-mapping of genomic loci associated with tobacco and alcohol use, to inform function of these loci via ancestry-aware transcriptome-wide association studies, and to evaluate the genetic architecture and predictive power of polygenic risk within and across populations. We found that increases in s

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Acidic, spicy, and fatty trigger foods Moderate

    These foods relax the esophageal sphincter and stimulate gastric acid production; rs10641969-T carriers have genetic predisposition to GERD/PUD.

    Identify and avoid personal triggers; common ones include citrus, chocolate, caffeine, fatty meats

  • Alcohol Moderate

    Alcohol reduces lower esophageal sphincter pressure and increases gastric acid secretion in those genetically susceptible to GERD/PUD.

    Limit or eliminate alcohol consumption

Lifestyle

  • Elevate head of bed during sleep Moderate

    Head elevation reduces supine reflux of gastric acid, particularly important for those genetically predisposed to GERD/PUD.

    Raise head 6-8 inches or use wedge pillow

  • Smoking Moderate

    Smoking relaxes the esophageal sphincter and impairs gastric mucosal defenses, compounding genetic GERD/PUD risk from rs10641969-T.

    Avoid smoking; use cessation strategies if currently smoking

  • Weight management if overweight Moderate

    Excess abdominal adiposity increases intragastric pressure and reduces esophageal sphincter tone, worsening reflux in genetically susceptible individuals.

    Maintain healthy BMI through balanced diet and regular exercise