rs1062557 - GRP

Magnitude 2.2 · 1 study on file

Reported associations

• Identification and characterization of the long non-coding RNA NFIA-AS2 as a novel locus for body mass index in American Indians - Unknown journal (n.d.) · Unknown authors · PubMed 36806387

  ABSTRACT: Background Genome-wide association studies have shown that body mass index (BMI), an estimate of obesity, is highly polygenic. Individual variants typically have small effect sizes, making it challenging to identify unique loci in under-represented ethnic groups which lack statistical power due to their small sample size. Yet obesity is a major health disparity and is particularly prevalent in southwestern American Indians. Here, we identify and characterize a new locus for BMI that was detected by analyzing moderate associations with BMI obtained in a population-based sample of southwestern American Indians together with the well-powered GIANT dataset. Methods Genotypes for 10.5 million variants were tested for association with BMI in 5870 American Indians and 2600 variants that

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