rs1060348 - HMGB1

Magnitude 2.0 · 1 study on file

Reported associations

• Genotype effects contribute to variation in longitudinal methylome patterns in older people - Unknown journal (n.d.) · Unknown authors · PubMed 30348214

  ABSTRACT: Background DNA methylation levels change along with age, but few studies have examined the variation in the rate of such changes between individuals. Methods We performed a longitudinal analysis to quantify the variation in the rate of change of DNA methylation between individuals using whole blood DNA methylation array profiles collected at 2-4 time points (N = 2894) in 954 individuals (67-90 years). Results After stringent quality control, we identified 1507 DNA methylation CpG sites (rsCpGs) with statistically significant variation in the rate of change (random slope) of DNA methylation among individuals in a mixed linear model analysis. Genes in the vicinity of these rsCpGs were found to be enriched in Homeobox transcription factors and the Wnt signalling pathway, bo

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