rs1060043 - SLC1A5, FKRP
Magnitude 4.5 · 1 study on file
Reported associations
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Genetic and environmental factors in conjunctival UV autofluorescence. - JAMA ophthalmology (2015) · Yazar S, Cuellar-Partida G, McKnight CM, Quach-Thanissorn P, Mountain JA, Coroneo MT, Pennell CE, Hewitt AW, MacGregor S, Mackey DA · PubMed 25590795
Conjunctival UV autofluorescence (CUVAF) photography was developed to detect and characterize preclinical sunlight-induced ocular damage. Ocular sun exposure has been related to cases of pterygia and was recently negatively correlated with myopia. Hence, CUVAF has excellent potential as an objective biomarker of sun exposure. However, much variation in CUVAF has been observed, and the relative contributions of genes and environment to this variation have not yet been identified. To investigate sources of variation in CUVAF in relation to its potential clinical relevance. We performed a cross-sectional analysis of 3 population-based cohort studies in the general community, including the Twins Eye Study in Tasmania, the Brisbane Adolescent Twin Study, and the Western Australian Pregnancy Coh
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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UV-protective sunglasses and hats during sun exposure Moderate
rs1060043 increases genetic susceptibility to conjunctival UV accumulation; modifiable sun exposure directly impacts CUVAF levels
Wear UVA/UVB-blocking sunglasses and wide-brimmed hat; limit unprotected exposure especially 10am-4pm
Screening
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ophthalmologic exam for ocular sun damage markers Moderate
rs1060043 increases conjunctival UV autofluorescence, an established biomarker of cumulative ocular UV exposure and pterygium risk
Baseline exam with pterygium assessment and CUVAF imaging if available; repeat every 2 years