Expressive

rs10590228 - POLR3C

Magnitude 2.2 · 1 study on file

Reported associations

  • Diversity and longitudinal records: Genetic architecture of disease associations and polygenic risk in the Taiwanese Han population - Unknown journal (n.d.) · Unknown authors · PubMed 40465716

    ABSTRACT: We addressed the underrepresentation of non-European populations in genome-wide association studies (GWASs) by building HiGenome, a large-scale genetic resource for the Taiwanese Han population. Using a custom genotyping array, we integrated deidentified electronic medical records (2003 to 2021) with genomic data to enable GWASs, phenome-wide association studies, and polygenic risk score (PRS) analysis. Among 413,000 participants, 323,397 passed ancestry and quality control filtering. GWASs covered 1085 traits, focusing on diseases prevalent in Taiwan such as type 2 diabetes, chronic kidney disease, gout, and alcoholic liver damage. PRSs were calculated for 238 traits, with the strongest associations observed in musculoskeletal disorders. Incorporating PRS into clinical practice

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • excessive alcohol, especially beer Moderate

    Alcohol increases serum uric acid and inhibits renal urate excretion; effect is amplified by genetic susceptibility

    Limit to one drink per day or less; minimize beer intake

  • high-purine foods Moderate

    Dietary purines are metabolized to uric acid; genetic variants increase gout susceptibility from purine intake

    Limit organ meats, red meat, certain shellfish, and high-fructose foods

Lifestyle

  • maintain adequate hydration Moderate

    Increased fluid intake enhances renal urate clearance and reduces gout risk in genetically susceptible individuals

    Drink at least 2 liters of water daily; increase with activity level

  • maintain healthy weight Moderate

    Obesity increases serum uric acid; weight reduction improves urate clearance and reduces gout attacks

    Achieve BMI 18.5-24.9 through balanced nutrition and regular physical activity

Screening

  • serum uric acid levels Moderate

    This SNP is associated with increased gout risk; periodic uric acid measurement detects hyperuricemia early

    Measure serum uric acid annually or as recommended by provider