Expressive

rs1055894680 - ZNF689

Magnitude 2.8 · 1 study on file

Reported associations

  • Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction - Unknown journal (n.d.) · Unknown authors · PubMed 36653681

    ABSTRACT: Atrial fibrillation (AF) is a common cardiac arrhythmia resulting in increased risk of stroke. Despite highly heritable etiology, our understanding of the genetic architecture of AF remains incomplete. Here we performed a genome-wide association study in the Japanese population comprising 9,826 cases among 150,272 individuals and identified East Asian-specific rare variants associated with AF. A cross-ancestry meta-analysis of >1 million individuals, including 77,690 cases, identified 35 new susceptibility loci. Transcriptome-wide association analysis identified IL6R as a putative causal gene, suggesting the involvement of immune responses. Integrative analysis with ChIP-seq data and functional assessment using human induced pluripotent stem cell-derived cardiomyocytes demonstrat

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Atrial fibrillation genetic risk and screening strategy High

    rs1055894680 in ZNF689 is a genome-wide significant risk variant for atrial fibrillation from large cross-ancestry GWAS analysis.

    Discuss AF risk assessment, screening options, and prevention with your physician.

Lifestyle

  • Blood pressure control High

    Systolic and diastolic blood pressure show strong causal relationship to atrial fibrillation development and should be managed in genetic risk carriers.

    Monitor blood pressure regularly, maintain target <130/80 mmHg per physician guidance.

  • Maintain healthy BMI High

    BMI is a significant predictor of atrial fibrillation risk; management may reduce AF development.

    Monitor BMI, maintain target 18.5-24.9 kg/m2, discuss weight management with physician.

Screening

  • Atrial fibrillation screening High

    Carriers of rs1055894680 have 1.215-fold increased risk for atrial fibrillation, which can cause stroke and cardiovascular complications.

    Baseline EKG and discuss AF screening protocol with physician.