rs1053023 - STAT3
Magnitude 2.2 · 1 study on file
Reported associations
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Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways - Unknown journal (n.d.) · Unknown authors · PubMed 36050321
ABSTRACT: The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration and JT interval, respectively. QT interval abnormalities are associated with potentially fatal ventricular arrhythmia. Using genome-wide multi-ancestry analyses (>250,000 individuals) we identify 177, 156 and 121 independent loci for QT, JT and QRS, respectively, including a male-specific X-chromosome locus. Using gene-based rare-variant methods, we identify associations with Mendelian disease genes. Enrichments are observed in established pathways for QT and JT, and previously unreported genes indicated in insulin-receptor signalling and cardiac energy metabolism. In contrast for QRS, connective tissue components and processes for ce
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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QT-prolonging medications with physician Moderate
Genetic predisposition to longer QT interval increases vulnerability to drug-induced torsades de pointes and cardiac arrhythmias
Lifestyle
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electrolyte balance, particularly potassium and magnesium Moderate
QT interval is sensitive to serum electrolyte levels; genetic predisposition to longer QT increases arrhythmia risk from electrolyte derangement
maintain adequate dietary intake and monitor if symptomatic
Screening
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baseline electrocardiogram for QT interval assessment Moderate
rs1053023 shows strong genome-wide association with QT interval duration; prolonged QT increases arrhythmia risk
obtain baseline 12-lead EKG