rs1052270 - TMOD1
Magnitude 4.5 · 1 study on file
Reported associations
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Genomic Variations in Susceptibility to Intracranial Aneurysm in the Korean Population - Unknown journal (n.d.) · Unknown authors · PubMed 30823506
ABSTRACT: Genome-wide association studies found genetic variations with modulatory effects for intracranial aneurysm (IA) formations in European and Japanese populations. We aimed to identify the susceptibility of single nucleotide polymorphisms (SNPs) to IA in a Korean population consisting of 250 patients, and 294 controls using the Asian-specific Axiom Precision Medicine Research Array. Twenty-nine SNPs reached a genome-wide significance threshold (5 × 10−8). The rs371331393 SNP, with a stop-gain function of ARHGAP32 (11q24.3), showed the most significant association with the risk of IA (OR = 43.57, 95% CI: 21.84-86.95; p = 9.3 × 10−27). Eight out of 29 SNPs-GBA (rs75822236), TCF24 (rs112859779), OLFML2A (rs79134766), ARHGAP32 (rs371331393), CD163L1 (rs138525217), CUL4A (rs741
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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intracranial aneurysm screening options Moderate
This SNP shows genome-wide significant association with intracranial aneurysm susceptibility in this population.
Discuss with physician whether neuroimaging screening (MRA or CTA) is appropriate, especially with family history of IA or SAH.
Lifestyle
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blood pressure through lifestyle modifications Moderate
Hypertension is a major modifiable risk factor for intracranial aneurysm formation.
Maintain healthy weight, limit dietary sodium, regular aerobic exercise (150 min/week), stress reduction.
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cigarette smoking Moderate
Smoking is a major risk factor for intracranial aneurysm formation; this SNP associates with IA susceptibility.
Complete smoking avoidance; seek cessation support if applicable.