Expressive

rs1052035 - PSMA4

Magnitude 2.2 · 2 studies on file

Reported associations

  • Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders - Unknown journal (n.d.) · Unknown authors · PubMed 37250466

    ABSTRACT: Genetic liability to substance use disorders can be parsed into loci that confer general or substance-specific addiction risk. We report a multivariate genome-wide association meta-analysis that disaggregates general and substance-specific loci for published summary statistics of problematic alcohol use, problematic tobacco use, cannabis use disorder, and opioid use disorder in a sample of 1,025,550 individuals of European descent and 92,630 individuals of African descent. Nineteen independent SNPs were genome-wide significant (P < 5e-8) for the general addiction risk factor (addiction-rf), which showed high polygenicity. Across ancestries, PDE4B was significant (among other genes), suggesting dopamine regulation as a cross-substance vulnerability. An addiction-rf polygenic risk

  • Pleiotropic genetic architecture and novel loci for C-reactive protein levels - Unknown journal (n.d.) · Unknown authors · PubMed 36376304

    ABSTRACT: C-reactive protein is involved in a plethora of pathophysiological conditions. Many genetic loci associated with C-reactive protein are annotated to lipid and glucose metabolism genes supporting common biological pathways between inflammation and metabolic traits. To identify novel pleiotropic loci, we perform multi-trait analysis of genome-wide association studies on C-reactive protein levels along with cardiometabolic traits, followed by a series of in silico analyses including colocalization, phenome-wide association studies and Mendelian randomization. We find 41 novel loci and 19 gene sets associated with C-reactive protein with various pleiotropic effects. Additionally, 41 variants colocalize between C-reactive protein and cardiometabolic risk factors and 12 of them display

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • genetic susceptibility to tobacco dependence High

    PSMA4 variants affect reward circuit development; associated with problematic tobacco use and increased cigarette consumption

    Discuss genetic predisposition and prevention strategies at next visit

Lifestyle

  • enhanced smoking cessation support Moderate

    PSMA4 variants affect reward circuitry; elevated addiction risk requires intensive intervention if tobacco use is present

    If currently smoking: combine pharmacotherapy (varenicline or NRT) with behavioral counseling

Screening

  • tobacco use screening High

    Variant associates with problematic tobacco use and higher cigarette consumption; linked to altered PSMA4 expression in brain reward regions involved in addiction

    Annual screening; discuss smoking history and patterns with healthcare provider