rs10518182 - CNOT6L - MRPL1

Magnitude 4.5 · 1 study on file

Reported associations

• Genetic risk loci for Parkinson's disease and dementia in a large-scale population-based Taiwanese cohort (TPMI) - Unknown journal (n.d.) · Unknown authors · PubMed 41810385

  ABSTRACT: Summary Background The genetic architecture of Parkinson's disease (PD) and progression to PD dementia (PDD) remains incompletely characterized in Asians. Here, we investigated genetic risk factors for PD and PDD in Taiwanese individuals from the Taiwan Precision Medicine Initiative (TPMI), the largest non-European cohort integrating genetic and electronic medical record data. Methods We conducted a two-stage population-based case-control genome-wide association study (GWAS) with a 1:10 case-to-control ratio. Results were meta-analyzed with an independent Asian GWAS. We further constructed a polygenic risk score (PRS) to distinguish PD cases from controls. PDD risk was assessed using logistic regression and Cox models, with replication in an independent cohort that underwent wh

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