rs10517287 - MAPRE1P2 - RPL31P31

Magnitude 2.0 · 1 study on file

Reported associations

• Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D - Unknown journal (n.d.) · Unknown authors · PubMed 22041458

  ABSTRACT: Background Understanding individual differences in susceptibility to antidepressant therapy side-effects is essential to optimize the treatment of depression. Method We performed genome-wide association studies (GWAS) to search for genetic variation affecting the susceptibility to side-effects. The analysis sample consisted of 1439 depression patients, successfully genotyped for 421K single nucleotide polymorphisms (SNPs), from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. Outcomes included four indicators of side-effects: general side-effect burden, sexual side-effects, dizziness and vision/hearing-related side-effects. Our criterion for genome-wide significance was a prespecified threshold ensuring that, on average, only 10% of the significant findi

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