rs10516541 - DKK2

Magnitude 2.0 · 1 study on file

Reported associations

• Framingham Heart Study genome-wide association: results for pulmonary function measures - BMC medical genetics (2007) · Wilk JB, Walter RE, Laramie JM, Gottlieb DJ, O'Connor GT · PubMed 17903307

  ABSTRACT: Background Pulmonary function measures obtained by spirometry are used to diagnose chronic obstructive pulmonary disease (COPD) and are highly heritable. We conducted genome-wide association (GWA) analyses (Affymetrix 100K SNP GeneChip) for measures of lung function in the Framingham Heart Study. Methods Ten spirometry phenotypes including percent of predicted measures, mean spirometry measures over two examinations, and rates of change based on forced expiratory volume in one second (FEV1), forced vital capacity (FVC), forced expiratory flow from the 25th to 75th percentile (FEF25-75), the FEV1/FVC ratio, and the FEF25-75/FVC ratio were examined. Percent predicted phenotypes were created using each participant's latest exam with spirometry. Predicted lung function was estima

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