rs10514688 - FECHP1 - KRT8P18

Magnitude 2.0 · 1 study on file

Reported associations

• Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness - Unknown journal (n.d.) · Unknown authors · PubMed 17903302

  ABSTRACT: Background About one quarter of adults are hypertensive and high blood pressure carries increased risk for heart disease, stroke, kidney disease and death. Increased arterial stiffness is a key factor in the pathogenesis of systolic hypertension and cardiovascular disease. Substantial heritability of blood-pressure (BP) and arterial-stiffness suggests important genetic contributions. Methods In Framingham Heart Study families, we analyzed genome-wide SNP (Affymetrix 100K GeneChip) associations with systolic (SBP) and diastolic (DBP) BP at a single examination in 1971-1975 (n = 1260), at a recent examination in 1998-2001 (n = 1233), and long-term averaged SBP and DBP from 1971-2001 (n = 1327, mean age 52 years, 54% women) and with arterial stiffness measured by arterial tono

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