rs10514650 - TDRD15 - NUTF2P8

Magnitude 4.5 · 1 study on file

Reported associations

• Depression in multiple sclerosis patients associated with risk variant near NEGR1. - Multiple sclerosis and related disorders (2021) · Brugger SW, Gardner MC, Beales JT, Briggs F, Davis MF · PubMed 33296963

  A substantial number of patients diagnosed with multiple sclerosis (MS) suffer from depression in addition to physical symptoms and disability. Recent evidence suggests a stronger relationship may exist between MS and depression than previously thought, in which a diagnosis of depression may be prodromic to the development of MS. A genome-wide association study (GWAS) was performed to identify genetic variants associated with the development of depression in a cohort of MS patients. The control group (n = 1180) was composed of MS patients with no diagnoses of depression as determined by ICD-9 and ICD-10 billing codes present in the electronic health record (EHR). Separate analyses were performed for three different case groups: 1) MS patients having a depression diagnosis at any time (n

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