Expressive

rs10514545 - MPHOSPH6-DT - CDH13

Magnitude 2.2 · 2 studies on file

Reported associations

  • Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome. - Nature genetics (2021) · Rühlemann MC, Hermes BM, Bang C, Doms S, Moitinho-Silva L, Thingholm LB, Frost F, Degenhardt F, Wittig M, Kässens J, Weiss FU, Peters A, Neuhaus K, Völker U, Völzke H, Homuth G, Weiss S, Grallert H, Laudes M, Lieb W, Haller D, Lerch MM, Baines JF, Franke A · PubMed 33462482

    The intestinal microbiome is implicated as an important modulating factor in multiple inflammatory , neurologic and neoplastic diseases . Recent genome-wide association studies yielded inconsistent, underpowered and rarely replicated results such that the role of human host genetics as a contributing factor to microbiome assembly and structure remains uncertain . Nevertheless, twin studies clearly suggest host genetics as a driver of microbiome composition . In a genome-wide association analysis of 8,956 German individuals, we identified 38 genetic loci to be associated with single bacteria and overall microbiome composition. Further analyses confirm the identified associations of ABO histo-blood groups and FUT2 secretor status with Bacteroides and Faecalibacterium spp. Mendelian randomiza

  • Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction - Unknown journal (n.d.) · Unknown authors · PubMed 34446935

    ABSTRACT: Behaviors and disorders related to self-regulation, such as substance use, antisocial behavior, and ADHD, are collectively referred to as externalizing and have shared genetic liability. We applied a multivariate approach that leverages genetic correlations among externalizing traits for genome-wide association analyses. By pooling data from ~1.5 million people, our approach is statistically more powerful than single-trait analyses and identifies more than 500 genetic loci. The loci were enriched for genes expressed in the brain and related to nervous system development. A polygenic score constructed from our results predicts a range of behavioral and medical outcomes that were not part of genome-wide analyses, including traits that until now lacked well-performing polygenic scor

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