rs10513312 - ZIC1
Magnitude 2.2 · 1 study on file
Reported associations
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Multivariate genomic analysis of 5 million people elucidates the genetic architecture of shared components of the metabolic syndrome - Unknown journal (n.d.) · Unknown authors · PubMed 39349817
ABSTRACT: Metabolic syndrome (MetS) is a complex hereditary condition comprising various metabolic traits as risk factors. Although the genetics of individual MetS components have been investigated actively through large-scale genome-wide association studies, the conjoint genetic architecture has not been fully elucidated. Here, we performed the largest multivariate genome-wide association study of MetS in Europe (nobserved = 4,947,860) by leveraging genetic correlation between MetS components. We identified 1,307 genetic loci associated with MetS that were enriched primarily in brain tissues. Using transcriptomic data, we identified 11 genes associated strongly with MetS. Our phenome-wide association and Mendelian randomization analyses highlighted associations of MetS with diverse di
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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limit refined carbohydrates and added sugars Moderate
Metabolic syndrome includes dysglycemia; reducing refined carbs improves insulin sensitivity and glucose control
Prioritize whole grains, legumes, vegetables; limit sugary drinks and processed foods
Lifestyle
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aerobic exercise Moderate
Regular exercise improves insulin sensitivity and metabolic markers; variant affects muscle metabolic function
150 minutes moderate-intensity aerobic activity per week
Screening
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metabolic syndrome parameters Moderate
rs10513312 is associated with metabolic syndrome (p=1e-9, n=1.3M); variant affects skeletal muscle ZIC1 expression
Assess waist circumference, fasting glucose, lipids, blood pressure annually starting age 30