rs10513309 - RPL21P71 - ZIC4
Magnitude 2.2 · 1 study on file
Reported associations
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The power of genetic diversity in genome-wide association studies of lipids - Unknown journal (n.d.) · Unknown authors · PubMed 34887591
ABSTRACT: Elevated blood lipid levels are heritable risk factors of cardiovascular disease with varying prevalence worldwide due to differing dietary patterns and medication use. Despite advances in prevention and treatment, particularly through the lowering of low-density lipoprotein cholesterol levels, heart disease remains the leading cause of death worldwide. Genome-wide association studies (GWAS) of blood lipid levels have led to important biological and clinical insights, as well as new drug targets, for cardiovascular disease. However, most previous GWAS have been conducted in European ancestry populations and may have missed genetic variants contributing to lipid level variation in other ancestry groups due to differences in allele frequencies, effect sizes, and linkage-disequilibr
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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Increase fiber and reduce saturated fat intake Moderate
Elevated non-HDL cholesterol from genetic predisposition can be partially mitigated through dietary patterns high in soluble fiber and low in saturated fat.
Target 10-15g soluble fiber daily from oats, beans, fruit; limit saturated fat to less than 7 percent of total calories.
Screening
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Non-HDL cholesterol Moderate
rs10513309 C allele associated with increased non-HDL cholesterol levels; genetic predisposition warrants regular assessment.
Measure non-HDL cholesterol at least annually; more frequently if baseline is elevated.