rs10510241 - CNTN4

Magnitude 2.2 · 1 study on file

Reported associations

• Genetically regulated expression underlies cellular sensitivity to chemotherapy in diverse populations. - Human molecular genetics (2021) · Mulford AJ, Wing C, Dolan ME, Wheeler HE · PubMed 33575800

  Most cancer chemotherapeutic agents are ineffective in a subset of patients; thus, it is important to consider the role of genetic variation in drug response. Lymphoblastoid cell lines (LCLs) in 1000 Genomes Project populations of diverse ancestries are a useful model for determining how genetic factors impact the variation in cytotoxicity. In our study, LCLs from three 1000 Genomes Project populations of diverse ancestries were previously treated with increasing concentrations of eight chemotherapeutic drugs, and cell growth inhibition was measured at each dose with half-maximal inhibitory concentration (IC50) or area under the dose-response curve (AUC) as our phenotype for each drug. We conducted both genome-wide association studies (GWAS) and transcriptome-wide association studies (TWAS

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